Conversion of C14-and cis-or trans-4-H3-L-proline to 4-hydroxy-L-proline and 4-oxo-L-proline by Streptomyces antibioticus.
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چکیده
26 Gerhart, J. C., and A. B. Pardee, in Synthesis and Structure of Macromolecules, Cold Spring Harbor Symposia on Quantitative Biology, vol. 28 (1963), p. 491. 27 Changeux, J. P., in Subunit Structure of Proteins, Brookhaven Symposia in Biology, no. 17 (1964), p. 232. 28 Antonini, E., J. Wyman, M. Brunori, J. F. Taylor, A. Rossi-Fanelli, and A. Caputo, J. Biol. Chem., 239, 907 (1964). 29 Gibson, Q. H., personal communication. 30 Rossi-Fanelli, A., and E. Antonini, J. Biol. Chem., 235, PC 4 (1960). 31 For a review of this work, see Rossi-Fanelli, A., E. Antonini, and A. Caputo, Advan. Protein Chem., 19, 105-122 (1964). 32 Ansevin, A. T., and D. A. Yphantis, Abstracts, 8th Annual Meeting of the Biophysical Society, Feb. 26-28, 1964, no. WB 12. 33 Guidotti, G., and L. C. Craig, these PROCEEDINGS, 50, 46 (1963). 34 Andrews, P., Biochem. J., 91, 222 (1964). 35 Ackers, G. K., and T. E. Thompson, these PROCEEDINGS, 53, 342 (1965). 36 Antonini, E., J. Wyman, E. Bucci, C. Fronticelli, and A. Rossi-Fanelli, J. Mol. Biol., 4, 368 (1962).
منابع مشابه
The biosynthesis of cis-4-hydroxy-L-proline in sandal (Santalum album L.).
Two isomers of hydroxyproline are present in sandal leaves (Santalum album L.), cis-4-hydroxy-Lproline in the free state (Radhakrishnan & Giri, 1954) and bound trans-4-hydroxy-L-proline, which forms a minor proportion (4%) of total hydroxyproline (Kuttan & Radhakrishnan, 1969). Bound trans-4-hydroxy-L-proline in plants (Lamport, 1965) is presumably synthesized by a mechanism similar to that in ...
متن کاملEpimerization of trans-4-hydroxy-L-proline to cis-4-hydroxy-D-proline during acid hydrolysis of collagen.
1. trans-4-Hydroxy-r,-proline is epimerized to &+hydroxy-n-proline under the conditions generally used for the hydrolysis of proteins for analyses of amino acids. 2. The cis epimer elutes from a column of UR-30 resin on a Beckman amino acid analyzer at the same time as threonine and hence would be undetected. 3. About 8% of the trans-4-hydroxy-L-proline in collagen can be epimerized to c&4-hydr...
متن کاملStudies on bound trans-4-hydroxy-L-proline in sandal (Santalum album L.).
1. trans-4-Hydroxy-l-proline was found to occur in the bound state in the leaves of sandal (Santalum album L.), in which large amounts of free cis-4-hydroxy-l-proline are also present. 2. Bound trans-4-hydroxy-l-proline was present, associated mainly with a ;wall' fraction and a ;soluble' fraction roughly in equal proportions. 3. Bound proline is present only in small amounts in the ;soluble' f...
متن کاملTransport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1.
Several proline derivatives such as L-azetidine-2-carboxylic acid, cis-4-hydroxy-L-proline, and 3,4-dehydro-DL-proline prevent procollagen from folding into a stable triple-helical conformation, thereby reducing excessive deposition of collagen in fibrotic processes and the growth of tumors. This study was performed to investigate whether the recently discovered human proton-coupled amino acid ...
متن کاملAmino acids in sandal (Santalum album L) with special reference to cis-4-hydroxy-l-proline and sym. homospermidine
Sandal (Santalum album L) contains several interesting amino acids and amines which are not seen in other plants. This includes cis-4-hydroxy-l-proline in free form in leaves, flowers and seeds while trans-4-hydroxy-l-proline in bound form. Traces of 3, 4 dehydroproline is also detected in sandal leaves. Biosynthesis of cis-4-hydroxy proline indicates that hydroxylation taken place at proline p...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 54 2 شماره
صفحات -
تاریخ انتشار 1965